🍒 Irfan Khan Meets MTV Roadies -- Ranvijay Picture # | Mtv roadies, Roadies, Rannvijay singh

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Actor Irrfan Khan talks about his role in the new movie Life of Pi, directed by Ang Lee and based on the best-selling novel of the same name. Khan also starred in Slumdog Millionaire, The Namesake and A Mighty Heart. Tilnise


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イルファン・カーン(Irrfan Khan) ロスは続く. 4月29日にイルファン・カーンが逝去して2週間ほどが過ぎようとしているが、. 私のように映画でしか彼を観たことにない者でも、いわゆるイルファン・カーン ロスをずっと


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Sanjay Kumar Bharti, Joshua A. Sommers, Sanket Awate, Marina A. Bellani, Irfan Khan, Lynda Bradley, Graeme A. King, Yeonee Seol, Venkatasubramanian Vidhyasagar, Yuliang Wu, Takuye Abe, Koji Kobayashi, Kazuo Shin-Ya, Hiroyuki​


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DNA binding and ATP hydrolysis was defective for both FANCJ-RC and FANCJ-HD, the latter showing greater reduction. Thus, a minimal threshold of FANCJ catalytic activity is required to overcome replication stress induced by aphidicolin or telomestatin, or to repair bleomycin-induced DNA breakage. Expression of FANCJ-RC or FANCJ-HD in fancj -cells failed to rescue cisplatin or mitomycin sensitivity. fancj -cells are sensitive to DNA interstrand cross-linking ICL and replication fork stalling drugs. FANCJ-RC was compromised in dimerization and helicase processivity, whereas DNA unwinding by FANCJ-HD was barely detectable. These findings have implications for therapeutic strategies relying on DNA cross-link sensitivity or heightened replication stress characteristic of cancer cells.

Of over 20 FA-linked genes, FANCJ uniquely encodes a DNA helicase and mutations are also associated with breast and ovarian cancer.

We delineated the source defects of two FA patient-derived FANCJ helicase domain mutations. AB - Irfan khan Anemia FA is characterized by bone irfan khan failure, congenital abnormalities, and cancer.

Live-cell imaging demonstrated a significantly compromised recruitment of FANCJ-RC to laser-induced DNA damage.